Metabolic Research

GLP-3 Research Guide

Research Overview

GLP-3 (LY3437943) is an investigational single-molecule peptide that acts as an agonist at three receptors: the glucose-dependent insulinotropic polypeptide receptor (GIPR), the glucagon-like peptide-1 receptor (GLP-1R), and the glucagon receptor (GCGR). It has been studied in preclinical and clinical metabolic research as a triple-hormone-receptor agonist. This is a research compound and is not intended for human consumption.

Structural & Class Overview

Investigational triple-agonist peptide acting across three class B G-protein-coupled receptors (GIPR, GLP-1R, GCGR). Combines incretin-receptor agonism with glucagon-receptor agonism in one molecule; part of the emerging multi-receptor incretin/glucagon peptide family.

General Research Interest

Research interest includes tri-agonist receptor pharmacology and signaling balance across three targets, energy-metabolism pathways in preclinical models, hepatic lipid content in laboratory steatosis models, and comparative study versus single- and dual-agonist incretin peptides.

Storage Considerations

Typically supplied as a lyophilized powder. General research handling keeps lyophilized material cold and protected from light and moisture; reconstituted solutions are generally refrigerated and used within a limited window. For laboratory research handling only.

Testing & Quality Considerations

Quality considerations include HPLC purity analysis, mass-spectrometry identity confirmation of the expected mass, and verification of each batch against its Certificate of Analysis (COA). Public research information on this compound is investigational and evolving; this page will be expanded as additional documentation is reviewed.

References

  1. Triple-Hormone-Receptor Agonist GLP-3 for Obesity — Phase 2 Trial (NEJM)
  2. A Study of GLP-3 (LY3437943) — ClinicalTrials.gov NCT05929066
  3. Triple hormone receptor agonist retatrutide for MASLD: phase 2a trial (Nature Medicine)

References are provided for scientific context. Linked sources are independent and not affiliated with iNGEN MD.

Research Use Only — Not For Human Consumption. All products sold by iNGEN MD are intended strictly for in-vitro laboratory and scientific research purposes only. These products are not approved by the FDA and are not intended for human or veterinary use, diagnosis, treatment, cure, or prevention of any disease. By purchasing, you confirm you are a qualified researcher aged 18 or older, acting in compliance with all applicable laws. iNGEN MD assumes no liability for misuse.