Recovery Research

GHK-Cu Research Guide

50mg · Research compound — not for human consumption

Research Overview

GHK-Cu is the copper(II) complex of the naturally occurring tripeptide glycyl-L-histidyl-L-lysine (Gly-His-Lys), first isolated from human plasma in 1973. It has been studied in fibroblast, connective-tissue, and gene-expression laboratory models for copper-dependent effects on extracellular-matrix and repair-related pathways. It is presented here as a research compound not intended for human consumption.

Structural & Class Overview

Copper-binding tripeptide complex; glycyl-L-histidyl-L-lysine (free peptide C14H24N6O4, PubChem CID 73587) coordinated 1:1 with copper(II), complex molecular weight approximately 403.9 g/mol. Mechanistically classed among matrix-modulating and copper-cofactor-delivery peptides; copper is a required cofactor for lysyl oxidase, which cross-links collagen and elastin.

General Research Interest

Research interest includes stimulation of collagen and glycosaminoglycan synthesis in fibroblast models; matrix-metalloproteinase (e.g., MMP-2) regulation; copper-dependent extracellular-matrix remodeling; antioxidant and anti-inflammatory signaling; and genome-wide gene-expression modulation reported across thousands of human genes in laboratory analyses. These are laboratory study areas, not established human benefits.

Storage Considerations

General research-handling notes for a lyophilized peptide complex: store the sealed lyophilized material cold, dry, and protected from light per supplier documentation; after reconstitution for laboratory use, refrigerate and minimize freeze-thaw cycles. Copper complexes are light-sensitive. Laboratory settings only. Not intended for human consumption.

Testing & Quality Considerations

Quality considerations include HPLC purity assessment, mass-spectrometry confirmation of peptide identity and molecular mass, verification of copper coordination/content, and review of a batch-specific Certificate of Analysis (COA).

References

  1. Glycyl-L-histidyl-L-lysine — PubChem CID 73587
  2. GHK and DNA: Resetting the Human Genome to Health, Pickart (2014)
  3. The Effect of the Human Peptide GHK on Gene Expression (PMC)

References are provided for scientific context. Linked sources are independent and not affiliated with iNGEN MD.

Research Use Only — Not For Human Consumption. All products sold by iNGEN MD are intended strictly for in-vitro laboratory and scientific research purposes only. These products are not approved by the FDA and are not intended for human or veterinary use, diagnosis, treatment, cure, or prevention of any disease. By purchasing, you confirm you are a qualified researcher aged 18 or older, acting in compliance with all applicable laws. iNGEN MD assumes no liability for misuse.