Performance Research

MGF Research Guide

2mg · Research compound — not for human consumption

Research Overview

MGF (Mechano Growth Factor), designated IGF-1Ec in humans, is a splice variant of the IGF-1 gene that has been studied as one of the early signaling peptides expressed after mechanical loading or muscle-fiber damage. Preclinical research has explored its role in muscle and neural tissue biology. It is a research compound not intended for human consumption.

Structural & Class Overview

Alternatively spliced isoform of IGF-1 produced via splicing of exons 5 and 6, yielding a distinct C-terminal E-peptide (Ec/Eb). The synthetic research peptide typically corresponds to this unique 24-residue E-domain, which shows signaling activity studied independently of the mature IGF-1 domain.

General Research Interest

Research interest includes activation of dormant muscle satellite cells; skeletal-muscle repair and hypertrophy models; neuroprotection and motoneuron survival in preclinical neurodegeneration models; neurogenesis studies in the aging rodent brain; and comparative signaling of the E-peptide versus full-length IGF-1.

Storage Considerations

General research-handling for a lyophilized peptide: store lyophilized material cold, dry, and away from light; after reconstitution in a suitable solvent, refrigerate and limit freeze-thaw cycles. For laboratory use only.

Testing & Quality Considerations

Quality considerations include HPLC purity determination, mass spectrometry for identity confirmation, and verification of batch Certificates of Analysis (COA) for peptide content, purity, and endotoxin where relevant.

References

  1. Mechano-growth factor, an IGF-I splice variant, rescues motoneurons (PubMed)
  2. MGF promotes neurogenesis in the aging mouse brain (PMC)

References are provided for scientific context. Linked sources are independent and not affiliated with iNGEN MD.

Research Use Only — Not For Human Consumption. All products sold by iNGEN MD are intended strictly for in-vitro laboratory and scientific research purposes only. These products are not approved by the FDA and are not intended for human or veterinary use, diagnosis, treatment, cure, or prevention of any disease. By purchasing, you confirm you are a qualified researcher aged 18 or older, acting in compliance with all applicable laws. iNGEN MD assumes no liability for misuse.