Performance Research

IGF-1 LR3 Research Guide

1mg · Research compound — not for human consumption

Research Overview

IGF-1 LR3 (Long Arg3 Insulin-like Growth Factor-1) is a synthetic 83-amino-acid analog of native IGF-1 that has been studied in laboratory settings as a tool for probing IGF-1 receptor signaling. Its structural modifications extend its in-vitro stability relative to native IGF-1. It is a research compound not intended for human consumption.

Structural & Class Overview

Modified single-chain polypeptide analog of the IGF-1 family; features an arginine-for-glutamic-acid substitution at position 3 plus a 13-residue N-terminal extension, which lower its affinity for IGF-binding proteins (IGFBPs). Mechanistically it is an agonist-class ligand of the IGF-1 receptor (IGF-1R), a receptor tyrosine kinase.

General Research Interest

Research interest includes IGF-1R receptor-tyrosine-kinase signaling pathways; interactions with IGF-binding proteins and altered ligand bioavailability in cell models; downstream PI3K/Akt and MAPK signaling studies; models of cell proliferation and differentiation; and comparative pharmacokinetic characterization versus native IGF-1 in preclinical assays.

Storage Considerations

General research-handling for a lyophilized peptide: store lyophilized material cold and protected from light and moisture; after reconstitution in a suitable laboratory solvent, keep refrigerated and minimize freeze-thaw cycles. For laboratory use only.

Testing & Quality Considerations

Quality considerations include HPLC assessment of purity, mass spectrometry for identity/molecular-weight confirmation, and verification of batch-specific Certificates of Analysis (COA) for peptide content and endotoxin where applicable.

References

  1. IGF-1 LR3 — Wikipedia
  2. IGF Binding Protein-2 Induces GLUT-4 Translocation and Glucose Uptake (PMC)

References are provided for scientific context. Linked sources are independent and not affiliated with iNGEN MD.

Research Use Only — Not For Human Consumption. All products sold by iNGEN MD are intended strictly for in-vitro laboratory and scientific research purposes only. These products are not approved by the FDA and are not intended for human or veterinary use, diagnosis, treatment, cure, or prevention of any disease. By purchasing, you confirm you are a qualified researcher aged 18 or older, acting in compliance with all applicable laws. iNGEN MD assumes no liability for misuse.