Performance Research

Follistatin Research Guide

Research Overview

Follistatin (FST) is an endogenous glycoprotein, encoded by the FST gene, that has been studied for its ability to bind and neutralize members of the TGF-beta superfamily, most notably myostatin (GDF-8) and activins. Preclinical research has explored its role in muscle and tissue biology. It is a research compound not intended for human consumption.

Structural & Class Overview

Secreted glycoprotein of the follistatin family; acts as a high-affinity antagonist-class binding protein for TGF-beta superfamily ligands including myostatin (GDF-8), activin A/B, and select bone morphogenetic proteins (BMPs). Common research variants include the FS-344 and FS-315 isoforms.

General Research Interest

Research interest includes myostatin and activin ligand-trap binding mechanisms; skeletal-muscle mass regulation in transgenic and gene-therapy rodent models; anti-fibrotic signaling; follicle-stimulating hormone (FSH) regulation; and preclinical models of neuromuscular disease biology.

Storage Considerations

General research-handling for a lyophilized protein: keep lyophilized material cold, dry, and protected from light; reconstitute with an appropriate laboratory buffer, store refrigerated or frozen per stability needs, and minimize freeze-thaw cycles. For laboratory use only.

Testing & Quality Considerations

Quality considerations include HPLC and/or SDS-PAGE purity assessment, mass spectrometry for identity confirmation, and review of batch Certificates of Analysis (COA) for content, purity, and endotoxin where applicable.

References

  1. Inhibition of Myostatin with Emphasis on Follistatin as a Therapy for Muscle Disease (PMC)
  2. Regulation of Muscle Mass by Follistatin and Activins (PMC)
  3. Discovery of a follistatin-derived myostatin inhibitory peptide (PubMed)

References are provided for scientific context. Linked sources are independent and not affiliated with iNGEN MD.

Research Use Only — Not For Human Consumption. All products sold by iNGEN MD are intended strictly for in-vitro laboratory and scientific research purposes only. These products are not approved by the FDA and are not intended for human or veterinary use, diagnosis, treatment, cure, or prevention of any disease. By purchasing, you confirm you are a qualified researcher aged 18 or older, acting in compliance with all applicable laws. iNGEN MD assumes no liability for misuse.