Cognitive / Longevity Research

Epitalon Research Guide

Research Overview

Epitalon (also spelled Epithalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly, AEDG) modeled on the amino acid composition of epithalamin, a pineal gland extract. Much of the existing research is preclinical (cell-culture and animal models), with limited peer-reviewed human data. Public research information on this compound is limited. This page will be expanded as additional documentation is reviewed. This is a research compound not intended for human consumption.

Structural & Class Overview

Synthetic tetrapeptide, sequence alanine-glutamic acid-aspartic acid-glycine (Ala-Glu-Asp-Gly / AEDG); a pineal-derived short-peptide bioregulator. Mechanism class studied in laboratory settings centers on modulation of telomerase activity and gene expression.

General Research Interest

Research interest includes telomerase activity and telomere-length changes in human somatic and fibroblast cell lines in vitro; alternative lengthening of telomeres (ALT) pathway activity; pineal/epithalamin-associated regulatory signaling; and gerontology-focused preclinical models of cellular senescence.

Storage Considerations

General handling for a lyophilized research peptide: keep lyophilized powder frozen and protected from light and moisture; refrigerate after reconstitution and minimize freeze-thaw cycles. For laboratory research use only.

Testing & Quality Considerations

Quality considerations include HPLC purity analysis, mass spectrometry for identity/molecular-weight confirmation, and verification against a batch-specific Certificate of Analysis (COA).

References

  1. Epithalon peptide induces telomerase activity and telomere elongation (PubMed)
  2. Epitalon increases telomere length in human cell lines (PMC)

References are provided for scientific context. Linked sources are independent and not affiliated with iNGEN MD.

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