Peptide Research

SS-31 Research Guide

10mg · Research compound — not for human consumption

Research Overview

SS-31 (also known as Elamipretide) is a mitochondria-targeting tetrapeptide with selective affinity for the inner mitochondrial membrane phospholipid cardiolipin. It has been studied in preclinical models and in sponsored clinical research programs focused on mitochondrial function. This is a research compound not intended for human consumption.

Structural & Class Overview

Synthetic tetrapeptide (Szeto-Schiller SS peptide class) characterized by alternating aromatic and basic residues that confer affinity for cardiolipin in the inner mitochondrial membrane. Mechanism class studied in laboratory settings involves membrane binding, modulation of surface electrostatics, and stabilization of electron-transport-chain organization.

General Research Interest

Research interest includes cardiolipin binding and inner-mitochondrial-membrane interactions; electron-transport-chain organization and ATP-synthesis efficiency in experimental systems; mitochondrial oxidative-stress and mitophagy models (e.g., Barth syndrome models); and sponsored clinical research programs in primary mitochondrial myopathy and related mitochondrial conditions.

Storage Considerations

General handling for a lyophilized research peptide: keep lyophilized powder frozen and protected from light and moisture; refrigerate after reconstitution and minimize freeze-thaw cycles. For laboratory research use only.

Testing & Quality Considerations

Quality considerations include HPLC purity analysis, mass spectrometry for identity/molecular-weight confirmation, and verification against a batch-specific Certificate of Analysis (COA).

References

  1. Mitochondrial protein interaction landscape of SS-31 (PMC)
  2. The mitochondria-targeted peptide SS-31 binds lipid bilayers (PMC)
  3. SS-31 ameliorates cardiac mitochondrial defects in a Barth syndrome model (Nature Sci Reports)

References are provided for scientific context. Linked sources are independent and not affiliated with iNGEN MD.

Research Use Only — Not For Human Consumption. All products sold by iNGEN MD are intended strictly for in-vitro laboratory and scientific research purposes only. These products are not approved by the FDA and are not intended for human or veterinary use, diagnosis, treatment, cure, or prevention of any disease. By purchasing, you confirm you are a qualified researcher aged 21 or older, acting in compliance with all applicable laws. iNGEN MD assumes no liability for misuse.